Genetics Times
Recent News |  Archives |  Tags |  About |  Newsletter |  Submit News |  Links |  Subscribe to GeneticsTimes.com RSS Feed Subscribe


More Articles
New material steals oxygen from the airNew material steals oxygen from the air

'Programmable' antibiotic harnesses an enzyme to attack drug-resistant microbes'Programmable' antibiotic harnesses an enzyme to attack drug-resistant microbes

Origin of moon's 'ocean of storms' revealedOrigin of moon's 'ocean of storms' revealed

More physical activity improved school performanceMore physical activity improved school performance

Building a bridge from basic botany to applied agricultureBuilding a bridge from basic botany to applied agriculture

Shape up quickly -- applies to fish, too!Shape up quickly -- applies to fish, too!

All directions are not created equal for nanoscale heat sourcesAll directions are not created equal for nanoscale heat sources

Engineering new vehicle powertrainsEngineering new vehicle powertrains

Stunning finds from ancient Greek shipwreckStunning finds from ancient Greek shipwreck

Pressing the accelerator on quantum roboticsPressing the accelerator on quantum robotics

Around the world in 400,000 years: The journey of the red foxAround the world in 400,000 years: The journey of the red fox

Active aging is much more than exerciseActive aging is much more than exercise

Making oxygen before lifeMaking oxygen before life

Gut bacteria, artificial sweeteners and glucose intoleranceGut bacteria, artificial sweeteners and glucose intolerance

Are the world's religions ready for ET?Are the world's religions ready for ET?

Protecting our processorsProtecting our processors

Researchers demonstrate direct fluid flow influences neuron growthResearchers demonstrate direct fluid flow influences neuron growth

Study: New device can slow, reverse heart failureStudy: New device can slow, reverse heart failure

First pictures of BRCA2 protein show how it works to repair DNAFirst pictures of BRCA2 protein show how it works to repair DNA

Chicxulub didn't do it all by itselfChicxulub didn't do it all by itself

Communication without detoursCommunication without detours

Laying the groundwork for data-driven scienceLaying the groundwork for data-driven science

Hold on, tiger momHold on, tiger mom

Nature's designs inspire research into new light-based technologiesNature's designs inspire research into new light-based technologies

Missing piece found to help solve concussion puzzleMissing piece found to help solve concussion puzzle

Biologists delay the aging process by 'remote control'Biologists delay the aging process by 'remote control'

Geography matters: Model predicts how local 'shocks' influence U.S. economyGeography matters: Model predicts how local 'shocks' influence U.S. economy

Identified for the first time what kind of explosive has been used after the detonationIdentified for the first time what kind of explosive has been used after the detonation

Copied from nature: Detecting software errors via genetic algorithmsCopied from nature: Detecting software errors via genetic algorithms

Tiny Genetic Differences Have Huge Consequences (1/20/2008)

Tags:
dna, rna, single nucleotide polymorphisms, snps, messenger rna, disease

The interaction of messenger RNA (mRNA) in a cell. Majewski and his colleagues have demonstrated that the natural processing of mRNA, via a process called splicing, is genetically controlled by single nucleotide polymorphisms (SNPs). (Credit: NHGRI/Talking Glossary of Genetics)
The interaction of messenger RNA (mRNA) in a cell. Majewski and his colleagues have demonstrated that the natural processing of mRNA, via a process called splicing, is genetically controlled by single nucleotide polymorphisms (SNPs). (Credit: NHGRI/Talking Glossary of Genetics)
A study led by McGill University researchers has demonstrated that small differences between individuals at the DNA level can lead to dramatic differences in the way genes produce proteins. These, in turn, are responsible for the vast array of differences in physical characteristics between individuals.

This study solves in part the mystery of how a relatively small number of differences within DNA protein coding sequences could be responsible for the enormous variety of phenotypic differences between individuals. It had previously been shown that individual differences reside in simple, relatively small variations in the DNA sequence called single nucleotide polymorphisms (SNPs, often pronounced "snips"), which exist primarily in the "junk code" of the DNA not previously known to have any profound genetic effect.

"There are many SNPs," explained Dr. Jacek Majewski of McGill University. "If you add them all together, you'd expect that two individuals would differ at more than a million of those positions. So we have a million or more small differences that distinguish you and me, and yet it would be very hard to explain all the phenotypic differences in the way we look, grow, and behave just by the handful of these protein coding differences."

Majewski and his colleagues have demonstrated that the natural processing of messenger RNA (mRNA), via a process called splicing, is genetically controlled by these SNPs. The SNPs in certain individuals lead to changes in splicing and result in the production of drastically altered forms of the protein. These out-of-proportion consequences may lead to the development of genetic diseases such as cystic fibrosis and Type 1 diabetes.

The study, part of the Genome Regulators in Disease (GRID) Project funded by Genome Canada and Genome Quebec, was led by Dr. Jacek Majewski of McGill University's Department of Human Genetics and the McGill University and Genome Quebec Innovation Centre, and first-authored by his research associate Dr. Tony Kwan. It was published January 13 in the journal Nature Genetics.

The study was originally initiated by Dr. Tom Hudson, former director of the McGill University and Genome Quebec Innovation Centre, and drew upon the data collected by the vast HapMap (Haplotype Map) Project, a global comparative map of the human genome, which Hudson and his colleagues were instrumental in completing.

Note: This story has been adapted from a news release issued by McGill University

Post Comments:

Search
New Articles
High-sugar diet no problem for genetic mutants

A tall story: Great strides in identifying genetic factors in height

A novel roadmap through bacterial genomes leads the way to new drug discovery

Liquid DNA behind virus attacks

Ebola genome browser now online to aid researchers' response to crisis

Twice the DNA yield in less time

Cattle code cracked in detail

RCas9: A programmable RNA editing toolRCas9: A programmable RNA editing tool

Proving 'group selection'

A new target for controlling inflammation? Long non-coding RNAs fine-tune the immune systemA new target for controlling inflammation? Long non-coding RNAs fine-tune the immune system

Geneticists solve 40-year-old dilemma to explain why duplicate genes remain in the genomeGeneticists solve 40-year-old dilemma to explain why duplicate genes remain in the genome

Gene interacts with stress and leads to heart disease in some people

New genetic 'operating system' facilitated evolution of 'bilateral' animals

Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence

Researchers discover potential biomarker to detect 'bubble boy' disorderResearchers discover potential biomarker to detect 'bubble boy' disorder



Archives
October 2014
September 2014
August 2014
July 2014
June 2014
May 2014
April 2014
March 2014
February 2014
January 2014
December 2013
November 2013
October 2013
September 2013
August 2013
July 2013
June 2013
May 2013
April 2013
March 2013
February 2013
January 2013
December 2012
November 2012
October 2012
September 2012
August 2012
July 2012
June 2012
May 2012
April 2012
March 2012
February 2012
January 2012
December 2011
November 2011
October 2011
September 2011
August 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2010
November 2010
October 2010
September 2010
August 2010
July 2010
June 2010
May 2010
April 2010
March 2010
February 2010
January 2010
December 2009
November 2009
October 2009
September 2009
August 2009
July 2009
June 2009
May 2009
April 2009
March 2009
February 2009
January 2009
December 2008
November 2008
October 2008
September 2008
August 2008
July 2008
June 2008
May 2008
April 2008
March 2008
February 2008
January 2008
October 2007
September 2007


Science Friends
Agricultural Science
Astronomy News
Biology News
Biomimicry Science
Cognitive Research
Chemistry News
Tissue Engineering
Cancer Research
Cybernetics Research
Electonics Research
Forensics Report
Fossil News
Genetic Archaeology
Geology News
Microbiology Research
Nanotech News
Parenting News
Physics News


  Archives |  Submit News |  Advertise With Us |  Contact Us |  Links
Use of this site constitutes acceptance of our Terms of Service and Privacy Policy. All contents © 2000 - 2015 Web Doodle, LLC. All rights reserved.