All Articles Tagged As: methylation
Researchers from the Institute of Psychiatry, King's College London, have identified numerous novel regions of the genome where the chemical modifications involved in controlling gene expression are influenced by either genetic variation or the parental origin of that particular stretch of DNA. This contradicts previous assumptions that epigenetic signals are generally equal across both copies of a given region of the genome, except at a small number of known imprinted genes.
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Identical twins look the same and are nearly genetically identical, but environmental factors and the resulting cellular changes could cause disease in one sibling and not the other. In a study published online in Genome Research, scientists have studied twins discordant for the autoimmune disease lupus, mapping DNA modifications across the genome and shedding light on epigenetic changes that may play a role in the disease.
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 | Using tiny crystals called quantum dots, Johns Hopkins researchers have developed a highly sensitive test to look for DNA attachments that often are early warning signs of cancer. ...> Full Article |
The discovery of a new nucleotide in the mouse brain opens the door to a new domain of epigenetic DNA modification
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 | Eric Selker's lab reports progress on biochemical communications among proteins involved in gene silencing ...> Full Article |
Study suggests that prenatal exposure to famine can lead to epigenetic changes that may affect a person's health into midlife. The findings show a trickle-down effect from pregnant women to the DNA of their unborn children and the timeframe over which such early damage can operate. These data are the first to show that early-life environmental conditions can cause epigenetic changes in humans that persist throughout life.
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Researchers have devised clever new techniques to mimic the chemical marks on tightly wound DNA-protein complexes that silence gene expression. The scientists have used these complexes to visualize gene silencing in its natural context for the first time.
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Scientists have determined the 3D structure of a key protein component involved in enabling "epigenetic code" to be copied accurately from cell to cell.
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Scientists have caught in action one of the tools mammalian cells use to maintain their pattern of methylation. Visualized by X-ray crystallography, the SRA domain of the protein UHRF1 appears to act like a bookmark while enzymes are copying a molecule of DNA.
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Enzymes regulating genetic expression can be just as important as the genome itself, increasing evidence shows
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 | Until recently, the chemical marks littering the DNA inside our cells like trees dotting a landscape could only be studied one gene at a time. But new high-throughput DNA sequencing technology has enabled researchers to map the precise position of these individual DNA modifications throughout the genome of the plant Arabidopsis thaliana, and chart its effect on the activity of any of Arabidopsis' roughly 26,000 genes. ...> Full Article |
New research may explain why eating royal jelly destines honeybee larvae to become queens instead of workers - and in the process adds new weight to the role of environmental factors in the nature/nurture divide.
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New high-throughput methods are revolutionizing our understanding of transcriptional regulation
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