All Articles Tagged As: stem cells
Singapore and US scientists have mapped major components of the epigenome and DNA methylation for the entire human DNA sequence, and compared three cell types representing three stages of human development.
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 | A team of biologists and engineers has dramatically improved the speed and accuracy of measuring histones, an enigmatic set of proteins that influences almost every aspect of how cells and tissues function. The new method offers a long-sought tool for studying stem cells, cancer and other problems of fundamental importance to biology and medicine.
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 | A strategy that combines gene therapy with blood stem cell therapy may be a useful tool for treating a fatal brain disease, French researchers have found. These findings appear in the Nov. 6, 2009, issue of the journal Science, which is published by AAAS, the nonprofit science society. ...> Full Article |
An international consortium of scientists, including researchers from the University of Queensland, have probed further into the human genome than ever before.
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The discovery of a new nucleotide in the mouse brain opens the door to a new domain of epigenetic DNA modification
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Most of the DNA in the nucleus of each of our cells is converted into RNA, but only a small fraction of these RNAs "code" for proteins. What the remaining "non-coding" RNAs (ncRNAs) do within cells is largely a mystery. Scientists at Cold Spring Harbor Laboratory have now uncovered a unique structure-building role for two ncRNAs, MENε and MENβ. They show that these RNAs organize and maintain the structure of nuclear compartments known as paraspeckles.
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Epigenetic finding adds insight on how cells become brain, liver -- and malignant
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Study provides new information on how stem cell differentiation is controlled by microRNAs.
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Plant architecture from the genomics toolbox
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Research uncovers critical molecular events underlying reprogramming of differentiated cells to a stem cell state
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 | Every minute, 30,000 of our outermost skin cells die so that we can live. When they do, new cells migrate from the inner layer of the skin to the surface of it, where they form a tough protective barrier. In a series of elegant experiments in mice, researchers at Rockefeller University have now discovered a tiny RNA molecule that helps create this barrier. The results not only yield new insight into how skin first evolved, but also suggest how healthy cells can turn cancerous. ...> Full Article |
A gene that "wakes up" the blood system's stem cells in times of stress also plays an important role in protecting against infection, said researchers from Baylor College of Medicine in Houston, the National Institute of Allergy and Infectious Disease and Duke University Medical School in a report that appears in the journal Cell Stem Cell.
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 | Genes, it turns out, are only as active as the signals that turn them on and off. Now scientists from Rockefeller University have identified the signaling molecule that ratchets up and clamps down the activity of key genes in dermal papilla, a type of skin cell whose unique collection of proteins ultimately instruct epithelial stem cells to make hair. ...> Full Article |
Scientists have accidentally discovered the genetics behind how we develop a front and back.
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The Stowers Institute's Trainor Lab has demonstrated the role of a gene important to the embryonic development of the nervous system, a process that requires coordination of differentiation of immature neural cells with the cycle of cell division that increases their numbers. Until now, the mechanisms regulating these distinct cellular activities have been poorly understood. The findings will be published in the Feb. 15 issue of Development.
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